Isolation of 39 polymorphic microsatellite loci and the development of a fluorescently labelled marker set for the Eurasian badger

We have isolated 78 microsatellite loci from the Eurasian badger (Meles meles). Of the 52 loci characterized, 39 were found to be polymorphic. A fluorescently labelled primer set was developed to enable individual-specific 17-locus genotypes to be obtained efficiently

On the nonlinear relationship between wall shear stress topology and multi-directionality in coronary atherosclerosis

Background and Objective: In this paper we investigate twelve multi-directional/topological wall shear stress (WSS) derived metrics and their relationships with the formation of coronary plaques in both computational fluid dynamics (CFD) and dynamic fluid-structure interaction (FSI) frameworks. While low WSS is one of the most established biomechanical markers associated with coronary atherosclerosis progression, alone it is limited. Multi-directional and topological WSS derived metrics have been shown to be important in atherosclerosis related mechanotransduction and near-wall transport processes. However, the relationships between these twelve WSS metrics and the influence of both FSI simulations and coronary dynamics is understudied. Methods: We first investigate the relationships between these twelve WSS derived metrics, stenosis percentage and lesion length through a parametric, transient CFD study. Secondly, we extend the parametric study to FSI, both with and without the addition of coronary dynamics, and assess their correlations. Finally, we present the case of a patient who underwent invasive coronary angiography and optical coherence tomography imaging at two time points 18 months apart. Associations between each of the twelve WSS derived metrics in CFD, static FSI and dynamic FSI simulations were assessed against areas of positive/negative vessel remodelling, and changes in plaque morphology. Results: 22–32% stenosis was the threshold beyond which adverse multi-directional/topological WSS results. Each metric produced a different relationship with changing stenoses and lesion length. Transient haemodynamics was impacted by coronary dynamics, with the topological shear variation index suppressed by up to 94%. These changes appear more critical at smaller stenosis levels, suggesting coronary dynamics could play a role in the earlier stages of atherosclerosis development. In the patient case, both dynamics and FSI vs CFD changes altered associations with measured changes in plaque morphology. An appendix of the linear fits between the various FSI- and CFD-based simulations is provided to assist in scaling CFD-based results to resemble the compliant walled characteristics of FSI more accurately. Conclusions: These results highlight the potential for coronary dynamics to alter multidirectional/topological WSS metrics which could impact associations with changes in coronary atherosclerosis over time. These results warrant further investigation in a wider range of morphological settings and longitudinal cohort studies in the future.Harry J. Carpenter, Mergen H. Ghayesha, Anthony C. Zander, Peter J. Psalti

QCD Corrections to K-Kbar Mixing in R-symmetric Supersymmetric Models

The leading-log QCD corrections to K-Kbar mixing in R-symmetric supersymmetric models are computed using effective field theory techniques. The spectrum topology where the gluino is significantly heavier than the squarks is motivated and focused on. It is found that, like in the MSSM, QCD corrections can tighten the kaon mass difference bound by roughly a factor of three. CP violation is also briefly considered, where QCD corrections can constrain phases to be as much as a factor of ten smaller than the uncorrected value.Comment: 11 pages, 11 pdf-figures; updated acknowledgments and references, clarified relationship to Ref[17], clarified CP-violation sectio

Identification of key astrophysical resonances relevant for the Al26g(p,γ)Si27 reaction in Wolf-Rayet stars, AGB stars, and classical novae

A γ-ray spectroscopy study of Al26g+p resonant states in Si27 is presented. Excitation energies were measured with improved precision and first spin-parity assignments made for excited states in Si27 above the proton threshold. The results indicate the presence of low-lying resonances with lp=0 and lp=2 captures that could strongly influence the Al26g(p,γ)Si27 reaction rate at low stellar temperatures, found in low-mass asymptotic giant branch (AGB), intermediate-mass AGB, super AGB, and Wolf-Rayet stars

Naturalness and Higgs Decays in the MSSM with a Singlet

The simplest extension of the supersymmetric standard model - the addition of one singlet superfield - can have a profound impact on the Higgs and its decays. We perform a general operator analysis of this scenario, focusing on the phenomenologically distinct scenarios that can arise, and not restricting the scope to the narrow framework of the NMSSM. We reexamine decays to four b quarks and four tau's, finding that they are still generally viable, but at the edge of LEP limits. We find a broad set of Higgs decay modes, some new, including those with four gluon final states, as well as more general six and eight parton final states. We find the phenomenology of these scenarios is dramatically impacted by operators typically ignored, specifically those arising from D-terms in the hidden sector, and those arising from weak-scale colored fields. In addition to sensitivity of m_Z, there are potential tunings of other aspects of the spectrum. In spite of this, these models can be very natural, with light stops and a Higgs as light as 82 GeV. These scenarios motivate further analyses of LEP data as well as studies of the detection capabilities of future colliders to the new decay channels presented.Comment: 3 figures, 1 appendix; version to appear in JHEP; typos fixed and additional references and acknowledgements adde

Identification of analog states in the T=1/2 A=27 mirror system from low excitation energies to the region of hydrogen burning in the 26Alg ,m(p,γ)27Si reactions

The reactions 26Alg(p,γ)27Si and 26Alm(p,γ)27Si are important for influencing the galactic abundance of the cosmic γ-ray emitter 26Alg and for the excess abundance of 26Mg found in presolar grains, respectively. Precise excitation energies and spin assignments of states from the ground state to the region of astrophysical interest in 27Si, including the identification and pairing of key astrophysical resonances with analog states in the mirror nucleus 27Al, are reported using γ rays observed in the 12C + 16O fusion reaction. The detailed evolution of Coulomb energy differences between the states in 27Si and 27Al is explored, including the region above the astrophysical reaction thresholds

Decay of the key 92-keV resonance in the 25Mg(p,γ) reaction to the ground and isomeric states of the cosmic γ-ray emitter 26Al

The 92-keV resonance in the 25Mg(p,γ)26Al reaction plays a key role in the production of 26Al at astrophysical burning temperatures of ≈100 MK in the Mg-Al cycle. However, the state can decay to feed either the ground, 26gAl, or isomeric state, 26mAl. It is the ground state that is critical as the source of cosmic γ rays. It is therefore important to precisely determine the ground-state branching fraction f0 of this resonance. Here we report on the identification of four γ-ray transitions from the 92-keV resonance, and determine the spin of the state and its ground-state branching fraction f0=0.52(2)stat(6)syst. The f0 value is the most precise reported to date, and at the lower end of the range of previously adopted values, implying a lower production rate of 26gAl and its cosmic 1809-keV γ rays.peerReviewe

Analog E1 transitions and isospin mixing

We investigate whether isospin mixing can be determined in a model-independent way from the relative strength of E1 transitions in mirror nuclei. The specific examples considered are the A=31 and A=35 mirror pairs, where a serious discrepancy between the strengths of 7/2--->5/2+ transitions in the respective mirror nuclei has been observed. A theoretical analysis of the problem suggests that it ought to be possible to disentangle the isospin mixing in the initial and final states given sufficient information on experimental matrix elements. With this in mind, we obtain a lifetime for the relevant 7/2- state in 31S using the Doppler-shift attenuation method. We then collate the available information on matrix elements to examine the level of isospin mixing for both A=31 and A=35 mirror pairs